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Home News and Update Year 2009 Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma

Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma

Polyphenolic compounds derived from tea catechins were examined for apoptosis–inducing activity in human histiolytic lymphoma U937 cells. (−)–Epigallocatechin gallate, theasinensin D, compound OH–5, theaflavin, and theaflavin digallate induced apoptosis as evidenced by DNA ladder formation, its inhibition by a caspase inhibitor, and chromatin condensation. Theasinensin D was the most potent inducer and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. These apoptosis–inducible compounds may be useful as a cancer chemopreventive and chemotherapeutic agent.

Source: http://www.jstage.jst.go.jp/

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