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Thursday, Apr 15th

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Home Cancer Cancer Topics What is a Clinical Trial?

What is a Clinical Trial?

What is a Clinical Trial?

  • A test of a new intervention or treatment on people.
Why are Clinical Trials conducted in Cancer?
  • To allow medical professionals and patients to gain information about the benefits, side effects and possible uses of new drugs as well as new ways to use existing drugs.
  • To translate results of basic scientific research into better ways to prevent, diagnose, or treat cancer.
Why do we need them?
  • We need to know that any treatments we recommend are both safe and effective in humans.
  • Cell culture and animal work can only take us so far!
  • Especially in Oncology, people are always looking for the miracle cure-and it is easy to get dragged into the idea.
  • Scientific, medical, evidence-based paradigm.
Types of Clinical Trials
  • Treatment Trials.
  • Prevention Trials.
  • Early-detection Trials/Screening Trials.
  • Diagnostic Trials.
  • Quality-of-life studies/supportive care studies.
  • Genetic Trials.
  • It can be a phase I, II or III trial.
  • It can be randomized or not.
  • It can be blinded or not.
  • It can involve a placebo or not.
  • And it can be a pilot study or not.
Phase I
Clinical Trials - Phase I
  • 15-30 people
  • Determines
    • What dose is safe.
    • How the treatment should given.
    • How the treatment affects the body.
    • Safety.

Phase II
Clinical Trials - Phase II
  • Less than 100 people.
  • Determines
    • Whether the treatment does what it is supposed to.
    • How the treatment affects the body.
    • If the drug or intervention has an effect on the cancer.
    • Does not compare with other treatments.


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