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Home News and Update Year 2009 Body's Own Protein can be Cancer Cure

Body's Own Protein can be Cancer Cure

Times of India
25 July 2009
New Delhi, India
By Kounteya Sinha

Last year, he hit the headlines for creating the world’s first breed of super mice, which are resistant to all forms of cancer. Now, Mumbai–born, US–settled, Vivek Rangnekar, professor of radiation medicine at the University of Kentucky, has in another breakthrough discovered that the Par–4 protein (mass killer of cancer cells) is produced within the human body and circulates to all organs.

This finding will now help scientists look at ways to naturally increase the secretion of the protein, for example, by certain natural diets. Scientists can also develop approaches to safely inject the Par–4 protein to inhibit cancer.

The team headed by Rangnekar has also found that Par–4 protein is capable of killing cancer cells when applied from outside. Till this discovery, scientists believed that Par–4 protein has to be present inside cancer cells to kill them.

Since it isn’t easy to deliver large amounts of the protein inside cancer cells, scientists have been studying other methods to target and kill cancer cells.

Par–4, after being secreted by human tissues, has been found to kill only cancer cells. It doesn’t harm normal cells. The presence of large amounts of the protein in the super mice had made them completely immune to cancer.

Par–4 Protein only Targets Cancer Cells
An Indian doctor has found that Body secretes cancer–busting protein. According to Dr Rangnekar, who is associate director of University of Kentucky’s Markey Cancer Center, what these findings mean for future is that it may not be necessary to use invasive or genetic approaches to inhibit growth of cancer.

“Par–4, secreted inside human body by kidney, lung and prostate, can now be developed so as to inject protein to treat cancer. Not only primary tumours, but also metastatic tumours that have spread to other tissues should be killed by Par–4 protein,’’ Dr Rangnekar, who spent over 25 years of his life in Mumbai, said.

“Increased Par–4 protein in circulation, in the blood and serum of the super mice, is one of the reasons they are resistant to cancer,” he added. According to his team, a person is susceptible to cancer when amount of this Par–4 protein secreted by cells of that individual is inadequate. “This needs to be tested on individual basis. The next step is to test whether human cancer can be prevented/treated by increa–sing amount of protein produced,” he said.

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